for full details of this exciting position focussed on the analysis of genetics and multi-omics data, to inform biological understanding in complex disease.

 Starting Salary for Research Assistant:  £28,756 to £30,497 per annum

Starting Salary for Research Associate:  £31,406 to £33,309 per annum

Closing Date:   10 February 2022

The Role

Your role will be to develop and apply advanced statistical analysis methods to multi-omics data (SNP genotypes,  gene-expression, CpG methylation and serum proteomics) derived from patients with liver disease and healthy controls, to identify causal pathways in disease development/progression. This is an exciting opportunity for a methodologically-focussed researcher with strong computational/statistical skills to contribute to cutting-edge methods development in a clinically relevant research area with strong translational potential.

The project forms part of a Wellcome Investigator Award in Science awarded to Professor Heather Cordell. The overall goal of this research is to develop and apply advanced statistical methods to help elucidate the biological mechanisms and causal pathways underpinning the correlations seen between genotype and phenotype in complex genetic disorders, with specific emphasis on liver and kidney disease. This will allow us to better understand the biological processes leading to disease development, thus enabling the development of potential therapies and cures. Identifying genes and their protein products which alter disease risk will point to potential new drug targets and allow opportunities for re-purposing of existing drugs. We will use measurements of genetic factors and potential intermediate processes such as gene expression, DNA methylation and protein levels, available through long-standing collaborations with clinical colleagues. A key goal of our research is to develop methods that integrate these different data types with one another, and with similar data from external sources.

This post is fixed term until 31st March 2026.

For informal enquiries contact: Professor Heather Cordell ([email protected])

Find out more about the Faculty of Medical Sciences here: https://www.ncl.ac.uk/medical-sciences/

Find out more about our Research Institutes here:  https://www.ncl.ac.uk/medical-sciences/research/institutes/