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Postdoctoral Scholar at the Intersection of Cancer, Dementia, and Genetic Epidemiology Institution: University of California, San Francisco (UCSF) Principal Investigator: Dr. Rebecca Graff, ScD Job Description Dr. Rebecca Graff at UCSF has an opening for an enthusiastic postdoctoral scholar interested in exploring the inverse relationship between cancer and Alzheimer’s disease and related dementias (AD/ADRD). Though both cancer and AD/ADRD generally increase with age, studies drawing on varied samples, study designs, and analytic approaches have found that each condition is associated with a reduced risk of the other. Diagnostic bias, selective survival, and competing risks were initially thought to explain the association, but several lines of evidence – largely collected in European ancestry populations – now indicate that these are unlikely holistic explanations. Dr. Graff has thus been awarded funding to investigate the following in the Kaiser Permanente Northern California membership and Multiethnic Cohort: 1) patterns of the inverse comorbidity between cancer and AD/ADRD, overall and by race/ethnicity, education, and age; 2) genome-wide, gene expression, and variant level genetic factors that may contribute to the inverse comorbidity; 3) lifestyle factors that may contribute to the inverse comorbidity; and 4) physiologic or treatment responses to cancer that reduce the risk of AD/ADRD. Applicants to this position should be eager to address these research imperatives, though they will also have the opportunity to contribute to other facets of Dr. Graff’s research portfolio. She also studies PSA genetics, the metabolomic basis of lethal prostate cancer, the role of lifestyle in prostate cancer survivorship, and the role of lifestyle in kidney cancer risk and survivorship. Essential Functions
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